Integrative epigenomics, transcriptomics and proteomics of patient chondrocytes reveal genes and pathways involved in osteoarthritis

@inproceedings{Steinberg2017IntegrativeET,
  title={Integrative epigenomics, transcriptomics and proteomics of patient chondrocytes reveal genes and pathways involved in osteoarthritis},
  author={Julia Steinberg and Graham R. S. Ritchie and Theodoros I. Roumeliotis and Raveen L Jayasuriya and Matthew J. Clark and Roger A. Brooks and A. Binch and Karan M Shah and Rachael E Coyle and Mercedes Pardo and Christine Lyn Le Maitre and Yolande F M Ramos and Rob G. H. H. Nelissen and Ingrid Meulenbelt and Andrew McCaskie and Jyoti S Choudhary and Jeremy Mark Wilkinson and Eleftheria Zeggini},
  booktitle={Scientific Reports},
  year={2017}
}
Osteoarthritis (OA) is a common disease characterized by cartilage degeneration and joint remodeling. The underlying molecular changes underpinning disease progression are incompletely understood. We investigated genes and pathways that mark OA progression in isolated primary chondrocytes taken from paired intact versus degraded articular cartilage samples across 38 patients undergoing joint replacement surgery (discovery cohort: 12 knee OA, replication cohorts: 17 knee OA, 9 hip OA patients… CONTINUE READING
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