Integrative biology identifies shared transcriptional networks in CKD.

  title={Integrative biology identifies shared transcriptional networks in CKD.},
  author={Sebastian Martini and Viji Nair and Benjamin J. Keller and Felix Eichinger and Jennifer J. Hawkins and Ann Randolph and Carsten Alexander B{\"o}ger and Crystal Ann Gadegbeku and Caroline Fox and Clemens David Cohen and Matthias Kretzler},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={25 11},
A previous meta-analysis of genome-wide association data by the Cohorts for Heart and Aging Research in Genomic Epidemiology and CKDGen consortia identified 16 loci associated with eGFR. To define how each of these single-nucleotide polymorphisms (SNPs) could affect renal function, we integrated GFR-associated loci with regulatory pathways, producing a molecular map of CKD. In kidney biopsy specimens from 157 European subjects representing nine different CKDs, renal transcript levels for 18… CONTINUE READING
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