Integrative bioinformatics and proteomics-based discovery of an eEF2K inhibitor (cefatrizine) with ER stress modulation in breast cancer cells.

@article{Yao2016IntegrativeBA,
  title={Integrative bioinformatics and proteomics-based discovery of an eEF2K inhibitor (cefatrizine) with ER stress modulation in breast cancer cells.},
  author={Zhiqiang Yao and Juntang Li and Zhongyu Liu and Lu Zheng and Naijun Fan and Ying Zhang and Nan Jia and Jingjing Lv and Ningning Liu and Xiaoshan Zhu and Jiangbo Du and Ci Lv and Feng Xie and Yigang Liu and Xingke Wang and Zhou Fei and Chunfang Gao},
  journal={Molecular bioSystems},
  year={2016},
  volume={12 3},
  pages={729-36}
}
Eukaryotic elongation factor-2 kinase (eEF2K), a unique calcium/calmodulin-dependent protein kinase, is well known to regulate apoptosis, autophagy and ER stress in many types of human cancers. Therefore, eEF2K would be regarded as a promising therapeutic target; however, the eEF2K-regulated mechanism and its targeted inhibitor still remain to be discovered in cancer. Herein, we constructed a protein-protein interaction (PPI) network of eEF2K and achieved an eEF2K-regulated ER stress subnetwork… CONTINUE READING
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