Integrative and comparative genomic analysis of lung squamous cell carcinomas in East Asian patients.

@article{Kim2014IntegrativeAC,
  title={Integrative and comparative genomic analysis of lung squamous cell carcinomas in East Asian patients.},
  author={Youngwook Kim and Peter S. Hammerman and Jaegil Kim and Ji-ae Yoon and Yoomi Lee and Jong-mu Sun and Matthew Wilkerson and Chandra Sekhar Pedamallu and Kristian Cibulskis and Yeong Kyung Yoo and Michael Sohn Lawrence and Petar Stojanov and Scott L. Carter and Aaron McKenna and Chip Stewart and Andrey Y. Sivachenko and In Jae Oh and Hong Kwan Kim and Yong Soo Choi and Kwhanmien Kim and Young Mog Shim and Kyu-Sik Kim and Sang-Yun Song and Kook-Joo Na and Yoon-La Choi and D. Neil Hayes and Jhingook Kim and Sukki Cho and Young Chul Kim and Jin Seok Ahn and Myung-ju Ahn and Gad Getz and Matthew Meyerson and Keunchil Park},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2014},
  volume={32 2},
  pages={121-8}
}
PURPOSE Lung squamous cell carcinoma (SCC) is the second most prevalent type of lung cancer. Currently, no targeted therapeutics are approved for treatment of this cancer, largely because of a lack of systematic understanding of the molecular pathogenesis of the disease. To identify therapeutic targets and perform comparative analyses of lung SCC, we probed somatic genome alterations of lung SCC by using samples from Korean patients. PATIENTS AND METHODS We performed whole-exome sequencing of… CONTINUE READING