Integrative analysis of prognostic factors in Chinese core binding factor leukemia.

@article{Wang2012IntegrativeAO,
  title={Integrative analysis of prognostic factors in Chinese core binding factor leukemia.},
  author={Di Wang and Chun Xia Qiao and Min Xiao and Zhe Geng and Zhen Shang and Jing He and Mei Huang and Yang Yang and Na Zhang and Yang Liu and Jianyong Li and Chunrui Li and Jianfeng Zhou},
  journal={Biochemical and biophysical research communications},
  year={2012},
  volume={428 3},
  pages={411-5}
}
The characteristics of core binding factor (CBF) leukemia appear to differ between Chinese and Caucasian patients. In this study, we analyzed the biological and clinical characteristics of 76 Chinese CBF leukemia patients out of 425 newly diagnosed acute myeloid leukemia (AML) patients. The frequency of CBF AML was 17.9%. Patients harboring t(8;21) were predominant in CBF AML. The incidence of c-kit mutation in CBF AML was 28.9%. The N822K mutation appeared to be more prevalent in Chinese CBF… CONTINUE READING