Integrative analysis of haplotype-resolved epigenomes across human tissues

  title={Integrative analysis of haplotype-resolved epigenomes across human tissues},
  author={Danny Leung and Inkyung Jung and Nisha Rajagopal and Anthony D. Schmitt and Siddarth Selvaraj and Ah Young Lee and Chia-An Yen and Shin Lin and Yiing Lin and Yunjiang Qiu and Wei Xie and Feng Yue and Manoj Hariharan and Pradipta Ray and S. N. Kuan and Lee E. Edsall and Hongbo Yang and Neil C Chi and Michael Q. Zhang and Joseph R. Ecker and Bing Ren},
Allelic differences between the two homologous chromosomes can affect the propensity of inheritance in humans; however, the extent of such differences in the human genome has yet to be fully explored. Here we delineate allelic chromatin modifications and transcriptomes among a broad set of human tissues, enabled by a chromosome-spanning haplotype reconstruction strategy. The resulting large collection of haplotype-resolved epigenomic maps reveals extensive allelic biases in both chromatin state… CONTINUE READING
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