Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis.

@article{Xia2009IntegrativeAO,
  title={Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis.},
  author={Xiaobo Xia and Madeleine E Lemieux and Wei Li and Jason S. Carroll and Myles Brown and Xiaole Shirley Liu and Andrew L Kung},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 11},
  pages={4260-5}
}
Adaptation to hypoxia is mediated through a coordinated transcriptional response driven largely by hypoxia-inducible factor 1 (HIF-1). We used ChIP-chip and gene expression profiling to identify direct targets of HIF-1 transactivation on a genome-wide scale. Several hundred direct HIF-1 targets were identified and, as expected, were highly enriched for proteins that facilitate metabolic adaptation to hypoxia. Surprisingly, there was also striking enrichment for the family of 2-oxoglutarate… CONTINUE READING
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