Integrative DNA Methylation and Gene Expression Analyses Identify DNA Packaging and Epigenetic Regulatory Genes Associated with Low Motility Sperm

@inproceedings{Pacheco2011IntegrativeDM,
  title={Integrative DNA Methylation and Gene Expression Analyses Identify DNA Packaging and Epigenetic Regulatory Genes Associated with Low Motility Sperm},
  author={Sara E. Pacheco and E. Andres Houseman and Brock C. Christensen and Carmen J. Marsit and Karl T. Kelsey and Mark Sigman and Kim Boekelheide},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND In previous studies using candidate gene approaches, low sperm count (oligospermia) has been associated with altered sperm mRNA content and DNA methylation in both imprinted and non-imprinted genes. We performed a genome-wide analysis of sperm DNA methylation and mRNA content to test for associations with sperm function. METHODS AND RESULTS Sperm DNA and mRNA were isolated from 21 men with a range of semen parameters presenting to a tertiary male reproductive health clinic. DNA… CONTINUE READING

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