Integrative Clinical Sequencing in the Management of Refractory or Relapsed Cancer in Youth.

  title={Integrative Clinical Sequencing in the Management of Refractory or Relapsed Cancer in Youth.},
  author={Rajen J Mody and Yi-mi Wu and Robert J. Lonigro and Xuhong Cao and Sameek Roychowdhury and Pankaj Vats and Kevin M. Frank and John R. Prensner and Irfan Ahmed Asangani and Nallasivam Palanisamy and Jonathan R Dillman and Raja M Rabah and Laxmi Priya Kunju and Jessica N. Everett and Victoria M Raymond and Yu Ning and Fengyun Su and Rui Wang and Elena M. Stoffel and Jeffrey W. Innis and J Scott Roberts and Patricia L. Robertson and Gregory Anthony Yanik and Aghiad Chamdin and James A Connelly and Sung Won Choi and Andrew C Harris and Carrie L. Kitko and Rama Jasty Rao and John E Levine and Valerie P. Castle and Raymond J. Hutchinson and Moshe Talpaz and D. R. T. Robinson and Arul M. Chinnaiyan},
  volume={314 9},
IMPORTANCE Cancer is caused by a diverse array of somatic and germline genomic aberrations. Advances in genomic sequencing technologies have improved the ability to detect these molecular aberrations with greater sensitivity. However, integrating them into clinical management in an individualized manner has proven challenging. OBJECTIVE To evaluate the use of integrative clinical sequencing and genetic counseling in the assessment and treatment of children and young adults with cancer… CONTINUE READING
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