Integrative Brain Transcriptome Analysis Reveals Region-Specific and Broad Molecular Changes in Shank3-Overexpressing Mice

@inproceedings{Jin2018IntegrativeBT,
  title={Integrative Brain Transcriptome Analysis Reveals Region-Specific and Broad Molecular Changes in Shank3-Overexpressing Mice},
  author={Chunmei Jin and Hyojin Kang and Jae Ryun Ryu and Shinhyun Kim and Yinhua Zhang and Yeunkum Lee and Yoonhee Kim and Kihoon Han},
  booktitle={Front. Mol. Neurosci.},
  year={2018}
}
Variants of the SH3 and multiple ankyrin repeat domain 3 (SHANK3) gene, encoding excitatory postsynaptic core scaffolding proteins, are causally associated with numerous neurodevelopmental and neuropsychiatric disorders, including autism spectrum disorder (ASD), bipolar disorder, intellectual disability, and schizophrenia (SCZ). Although detailed synaptic changes of various Shank3 mutant mice have been well characterized, broader downstream molecular changes, including direct and indirect… CONTINUE READING
1
Twitter Mention

References

Publications referenced by this paper.
SHOWING 1-10 OF 68 REFERENCES

The evolutionarily conserved G protein-coupled receptor SREB2/GPR85 influences brain size, behavior, and vulnerability to schizophrenia.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2008
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL