Integrative Brain Transcriptome Analysis Reveals Region-Specific and Broad Molecular Changes in Shank3-Overexpressing Mice

@article{Jin2018IntegrativeBT,
  title={Integrative Brain Transcriptome Analysis Reveals Region-Specific and Broad Molecular Changes in Shank3-Overexpressing Mice},
  author={Chunmei Jin and Hyojin Kang and J. Ryu and Shinhyun Kim and Yinhua Zhang and Yeunkum Lee and Y. Kim and Kihoon Han},
  journal={Frontiers in Molecular Neuroscience},
  year={2018},
  volume={11}
}
  • Chunmei Jin, Hyojin Kang, +5 authors Kihoon Han
  • Published 2018
  • Biology, Medicine
  • Frontiers in Molecular Neuroscience
  • Variants of the SH3 and multiple ankyrin repeat domain 3 (SHANK3) gene, encoding excitatory postsynaptic core scaffolding proteins, are causally associated with numerous neurodevelopmental and neuropsychiatric disorders, including autism spectrum disorder (ASD), bipolar disorder, intellectual disability, and schizophrenia (SCZ). Although detailed synaptic changes of various Shank3 mutant mice have been well characterized, broader downstream molecular changes, including direct and indirect… CONTINUE READING
    10 Citations
    Transcriptome analysis of Shank3-overexpressing mice reveals unique molecular changes in the hypothalamus
    • 2
    Uncovering the Functional Link Between SHANK3 Deletions and Deficiency in Neurodevelopment Using iPSC-Derived Human Neurons
    • 14
    • Highly Influenced
    • PDF

    References

    SHOWING 1-10 OF 74 REFERENCES
    Integrative Analysis of Brain Region-specific Shank3 Interactomes for Understanding the Heterogeneity of Neuronal Pathophysiology Related to SHANK3 Mutations
    • 13
    • PDF
    Striatal Transcriptome and Interactome Analysis of Shank3-overexpressing Mice Reveals the Connectivity between Shank3 and mTORC1 Signaling
    • 20
    • PDF
    Post-transcriptional regulation of SHANK3 expression by microRNAs related to multiple neuropsychiatric disorders
    • 35
    Brain region-specific disruption of Shank3 in mice reveals a dissociation for cortical and striatal circuits in autism-related behaviors
    • 33
    • PDF
    Shank3-mutant mice lacking exon 9 show altered excitation/inhibition balance, enhanced rearing, and spatial memory deficit
    • 94
    • PDF