Integrative Analysis of DNA Methylation Identified 12 Signature Genes Specific to Metastatic ccRCC

@article{Qian2020IntegrativeAO,
  title={Integrative Analysis of DNA Methylation Identified 12 Signature Genes Specific to Metastatic ccRCC},
  author={Siwei Qian and Si Sun and Lei Zhang and Shengwei Tian and Kaiqiang Xu and Guangyuan Zhang and Ming Chen},
  journal={Frontiers in Oncology},
  year={2020},
  volume={10}
}
Background: Abnormal epigenetic alterations can contribute to the development of human malignancies. Identification of these alterations for early screening and prognosis of clear cell renal cell carcinoma (ccRCC) has been a highly sought-after goal. Bioinformatic analysis of DNA methylation data provides broad prospects for discovery of epigenetic biomarkers. However, there is short of exploration of methylation-driven genes of ccRCC. Methods: Gene expression data and DNA methylation data in… 

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