Integrative (epi) Genomic Analysis to Predict Response to Androgen-Deprivation Therapy in Prostate Cancer

@inproceedings{Panja2018IntegrativeG,
  title={Integrative (epi) Genomic Analysis to Predict Response to Androgen-Deprivation Therapy in Prostate Cancer},
  author={Sukanya Panja and Sheida Hayati and Nusrat J Epsi and James Scott Parrott and Antonina Mitrofanova},
  booktitle={EBioMedicine},
  year={2018}
}
Therapeutic resistance is a central problem in clinical oncology. We have developed a systematic genome-wide computational methodology to allow prioritization of patients with favorable and poor therapeutic response. Our method, which integrates DNA methylation and mRNA expression data, uncovered a panel of 5 differentially methylated sites, which explain… CONTINUE READING