Integration specificity of retrotransposons and retroviruses.

  title={Integration specificity of retrotransposons and retroviruses.},
  author={Suzanne B. Sandmeyer and Leif Hansen and Douglas L Chalker},
  journal={Annual review of genetics},
Analysis of in vivo integration patterns has provided no data to support the notion that retroelement integration is random. Rather, the diversity of insertion patterns of retroelements suggests numerous ways in which genomic DNA is identified for preferential targeting. These range from specific to general and include sequence content, removal of chromatin proteins, nuclear localization, distinctive topology, and association with particular trans-acting factors. Many are similar to mechanisms… CONTINUE READING


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