Integration sites of human papillomavirus 18 DNA sequences on HeLa cell chromosomes.

@article{Popescu1987IntegrationSO,
  title={Integration sites of human papillomavirus 18 DNA sequences on HeLa cell chromosomes.},
  author={Nicholas C. Popescu and Joseph A Dipaolo and Suzanne C. Amsbaugh},
  journal={Cytogenetics and cell genetics},
  year={1987},
  volume={44 1},
  pages={58-62}
}
Human papillomaviruses (HPV) 16 and 18 are closely linked with human genital cancer. In most cervical carcinomas, viral sequences are integrated into the host genome. HeLa, a cervical carcinoma cell line, has multiple copies of integrated HPV 18 DNA. In this study, in situ chromosome hybridization was used to assign the integration sites of HPV 18 DNA sequences on HeLa cell chromosomes. Four sites of hybridization were identified at 8q23----q24, 9q31----q34, p11----p13 on an abnormal chromosome… CONTINUE READING