Integration site selection by retroviruses.

  title={Integration site selection by retroviruses.},
  author={Anna Cereseto and Mauro Giacca},
  journal={AIDS reviews},
  volume={6 1},
Integration into the host-cell genome is a critical step in the retrovirus life cycle. In particular, the choice of the integration site is crucial for retroviral replication, since integration at a site incompatible for high-level transcription may impair production of the progeny virus. Integration is not sequence specific, thus all chromosomal sites could potentially host integration events. However, this is not what is observed in vivo, where integrated viruses are preferentially detected… CONTINUE READING
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