Integration of troponin I phosphorylation with cardiac regulatory networks.

  title={Integration of troponin I phosphorylation with cardiac regulatory networks.},
  author={R. John Solaro and Marcus Henze and Tomoyoshi Kobayashi},
  journal={Circulation research},
  volume={112 2},
We focus here on the modulation of thin filament activity by cardiac troponin I phosphorylation as an integral and adaptive mechanism in cardiac homeostasis and as a mechanism vulnerable to maladaptive response to stress. We discuss a current concept of cardiac troponin I function in the A-band region of the sarcomere and potential signaling to cardiac troponin I in a network involving the ends of the thin filaments at the Z-disk and the M-band regions. The cardiac sarcomere represents a… CONTINUE READING
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