Integration of transforming growth factor beta and RAS signaling silences a RAB5 guanine nucleotide exchange factor and enhances growth factor-directed cell migration.

@article{Hu2008IntegrationOT,
  title={Integration of transforming growth factor beta and RAS signaling silences a RAB5 guanine nucleotide exchange factor and enhances growth factor-directed cell migration.},
  author={Hailiang Hu and Marc Milstein and Joanne M. Bliss and M. Sc. Pham Hong Thai and Gautam Malhotra and Lucia C. Huynh and John Colicelli},
  journal={Molecular and cellular biology},
  year={2008},
  volume={28 5},
  pages={1573-83}
}
Transforming growth factor beta (TGF-beta) receptor (TbetaR) signaling contributes to normal development as well as tumorigenesis. Here we report that RIN1, a RAB5 guanine nucleotide exchange factor (GEF) and down regulator of receptor tyrosine kinases (RTKs), promotes TbetaR signaling through enhanced endocytosis. TbetaR activation induces SNAI1 (Snail), a transcription repressor that reduces RIN1 expression, providing a negative feedback mechanism to control TbetaR trafficking and downstream… CONTINUE READING
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