Integration of the transcriptional networks regulating limb morphogenesis.

  title={Integration of the transcriptional networks regulating limb morphogenesis.},
  author={Adam H Rabinowitz and Steven A Vokes},
  journal={Developmental biology},
  volume={368 2},
The developing limb is one of the best described vertebrate systems for understanding how coordinated gene expression during embryogenesis leads to the structures present in the mature organism. This knowledge, derived from decades of research, is largely based upon gain- and loss-of-function experiments. These studies have provided limited information about how the key signaling pathways interact with each other and the downstream effectors of these pathways. We summarize our current… CONTINUE READING
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