Integration of tail-anchored proteins into the mitochondrial outer membrane does not require any known import components.

@article{Kemper2008IntegrationOT,
  title={Integration of tail-anchored proteins into the mitochondrial outer membrane does not require any known import components.},
  author={Christian Kemper and Shukry J. Habib and Gertraud Engl and Petra Heckmeyer and Kai Stefan Dimmer and Doron Rapaport},
  journal={Journal of cell science},
  year={2008},
  volume={121 Pt 12},
  pages={1990-8}
}
Tail-anchored proteins form a distinct class of membrane proteins that are found in all intracellular membranes exposed to the cytosol. These proteins have a single membrane insertion sequence at their C-terminus and display a large N-terminal portion to the cytosol. Despite their importance for various cellular processes, the mechanisms by which these proteins are recognized at and inserted into their corresponding target membrane remained largely unclear. Here we address this issue and… CONTINUE READING