Integration of stress responses: modulation of calcineurin signaling in Saccharomyces cerevisiae by protein kinase A.

@article{Kafadar2004IntegrationOS,
  title={Integration of stress responses: modulation of calcineurin signaling in Saccharomyces cerevisiae by protein kinase A.},
  author={Kimberly A Kafadar and Martha S. Cyert},
  journal={Eukaryotic cell},
  year={2004},
  volume={3 5},
  pages={1147-53}
}
Calcineurin is a Ca2+/calmodulin-dependent protein phosphatase required for Saccharomyces cerevisiae to adapt to a variety of environmental stresses. Once activated, calcineurin dephosphorylates the Zn-finger transcription factor Crz1p/Tcn1p, causing it to accumulate in the nucleus where it activates gene expression. Here we show that cyclic AMP-dependent protein kinase A (PKA) phosphorylates and negatively regulates Crz1p activity by inhibiting its nuclear import. Activation of PKA in vivo… CONTINUE READING

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