Integration of sodium and osmosensory signals in vasopressin neurons.

  title={Integration of sodium and osmosensory signals in vasopressin neurons.},
  author={Daniel L. Voisin and Charles W. Bourque},
  journal={Trends in neurosciences},
  volume={25 4},
Vasopressin (antidiuretic hormone) release has been thought to be controlled by interacting osmoreceptors and Na(+)-detectors for > 20 years. Only recently, however, have molecular and cellular advances revealed how changes in the external concentration of Na+ and osmolality are detected during acute and chronic osmotic perturbations. In rat vasopressin-containing neurons, local osmosensitivity is conferred by intrinsic stretch-inactivated cation channels and by taurine release from surrounding… CONTINUE READING

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