Integration of signaling pathways regulating chondrocyte differentiation during endochondral bone formation.

@article{Adams2007IntegrationOS,
  title={Integration of signaling pathways regulating chondrocyte differentiation during endochondral bone formation.},
  author={Sherrill L. Adams and Arthur J. Cohen and Luisa Lassov{\'a}},
  journal={Journal of cellular physiology},
  year={2007},
  volume={213 3},
  pages={635-41}
}
During endochondral bone formation, chondrocytes undergo a process of terminal differentiation or maturation, during which the rate of proliferation decreases, cells become hypertrophic, and the extracellular matrix is altered by production of a unique protein, collagen X, as well as proteins that promote mineralization. The matrix surrounding the hypertrophic chondrocytes eventually becomes mineralized, and the mineralized matrix serves as a template for bone deposition. This process is… CONTINUE READING