Integration of sequence-similarity and functional association information can overcome intrinsic problems in orthology mapping across bacterial genomes

@inproceedings{Li2011IntegrationOS,
  title={Integration of sequence-similarity and functional association information can overcome intrinsic problems in orthology mapping across bacterial genomes},
  author={Guojun Li and Qin Ma and Xizeng Mao and Yanbin Yin and Xiaoran Zhu and Ying Xu},
  booktitle={Nucleic acids research},
  year={2011}
}
Existing methods for orthologous gene mapping suffer from two general problems: (i) they are computationally too slow and their results are difficult to interpret for automated large-scale applications when based on phylogenetic analyses; or (ii) they are too prone to making mistakes in dealing with complex situations involving horizontal gene transfers and gene fusion due to the lack of a sound basis when based on sequence similarity information. We present a novel algorithm, Global… CONTINUE READING
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EGM: encapsulated gene-by-gene matching to identify gene orthologs and homologous segments

K. Mahmood, A. S. Konagurthu, +3 authors J. C. Whisstock
in genomes. Bioinformatics, • 2010

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