Integration of rotation and piston motions in coiled-coil signal transduction.

@article{Gao2007IntegrationOR,
  title={Integration of rotation and piston motions in coiled-coil signal transduction.},
  author={Rong Gao and David G Lynn},
  journal={Journal of bacteriology},
  year={2007},
  volume={189 16},
  pages={6048-56}
}
A coordinated response to a complex and dynamic environment requires an organism to simultaneously monitor and interpret multiple signaling cues. In bacteria and some eukaryotes, environmental responses depend on the histidine autokinases (HKs). For example, VirA, a large integral membrane HK from Agrobacterium tumefaciens, regulates the expression of virulence genes in response to signals from multiple molecular classes (phenol, pH, and sugar). The ability of this pathogen to perceive inputs… CONTINUE READING

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