Integration of regulatory networks by NKX3-1 promotes androgen-dependent prostate cancer survival.

@article{Tan2012IntegrationOR,
  title={Integration of regulatory networks by NKX3-1 promotes androgen-dependent prostate cancer survival.},
  author={Peck Yean Tan and Cheng Wei Chang and Kern Rei Chng and K Disnika Senali Abayratna Wansa and Wing-Kin Sung and Edwin Cheung},
  journal={Molecular and cellular biology},
  year={2012},
  volume={32 2},
  pages={399-414}
}
The NKX3-1 gene is a homeobox gene required for prostate tumor progression, but how it functions is unclear. Here, using chromatin immunoprecipitation coupled to massively parallel sequencing (ChIP-seq) we showed that NKX3-1 colocalizes with the androgen receptor (AR) across the prostate cancer genome. We uncovered two distinct mechanisms by which NKX3-1 controls the AR transcriptional network in prostate cancer. First, NKX3-1 and AR directly regulate each other in a feed-forward regulatory… CONTINUE READING
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