Integration of prolactin and glucocorticoid signaling at the beta-casein promoter and enhancer by ordered recruitment of specific transcription factors and chromatin modifiers.

@article{Kabotyanski2006IntegrationOP,
  title={Integration of prolactin and glucocorticoid signaling at the beta-casein promoter and enhancer by ordered recruitment of specific transcription factors and chromatin modifiers.},
  author={Elena B. Kabotyanski and Markus Huetter and W X Xian and Monique Rijnkels and Jeffrey M. Rosen},
  journal={Molecular endocrinology},
  year={2006},
  volume={20 10},
  pages={2355-68}
}
Lactogenic hormone regulation of beta-casein gene expression in mammary epithelial cells provides an excellent system in which to perform kinetic studies of chromatin remodeling and transcriptional activation. Using HC11 cells as a model, we have investigated the effects of prolactin (Prl) and glucocorticoids both singly and in combination at different time points after hormone treatment. Using chromatin immunoprecipitation analysis, we have determined the dynamics of assembly and disassembly… CONTINUE READING

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