Integration of mRNP formation and export

  title={Integration of mRNP formation and export},
  author={Petra Bj{\"o}rk and Lars Wieslander},
  booktitle={Cellular and Molecular Life Sciences},
Expression of protein-coding genes in eukaryotes relies on the coordinated action of many sophisticated molecular machineries. Transcription produces precursor mRNAs (pre-mRNAs) and the active gene provides an environment in which the pre-mRNAs are processed, folded, and assembled into RNA–protein (RNP) complexes. The dynamic pre-mRNPs incorporate the growing transcript, proteins, and the processing machineries, as well as the specific protein marks left after processing that are essential for… CONTINUE READING