Integration of in vitro data into allometric scaling to predict hepatic metabolic clearance in man: application to 10 extensively metabolized drugs.

@article{Lav1997IntegrationOI,
  title={Integration of in vitro data into allometric scaling to predict hepatic metabolic clearance in man: application to 10 extensively metabolized drugs.},
  author={Thierry Lav{\'e} and Sylvie Dupin and Christophe Schmitt and Robert Chang-Chih Chou and Daniel Jaeck and Philippe Coassolo},
  journal={Journal of pharmaceutical sciences},
  year={1997},
  volume={86 5},
  pages={584-90}
}
In this study, we investigated rational and reliable methods of using animal data to predict in humans the clearance of drugs which are mainly eliminated through hepatic metabolism. For 10 extensively metabolized compounds, adjusting the in vivo clearance in the different animal species for the relative rates of metabolism in vitro dramatically improved the predictions of human clearance compared to the approach in which clearance is directly extrapolated using body weight. Using hepatocyte… CONTINUE READING

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