Integration of human sleep-wake regulation and circadian rhythmicity.

@article{Dijk2002IntegrationOH,
  title={Integration of human sleep-wake regulation and circadian rhythmicity.},
  author={Derk-Jan Dijk and Steven W. Lockley},
  journal={Journal of applied physiology},
  year={2002},
  volume={92 2},
  pages={
          852-62
        }
}
  • D. Dijk, S. Lockley
  • Published 1 February 2002
  • Biology, Psychology
  • Journal of applied physiology
The human sleep-wake cycle is generated by a circadian process, originating from the suprachiasmatic nuclei, in interaction with a separate oscillatory process: the sleep homeostat. The sleep-wake cycle is normally timed to occur at a specific phase relative to the external cycle of light-dark exposure. It is also timed at a specific phase relative to internal circadian rhythms, such as the pineal melatonin rhythm, the circadian sleep-wake propensity rhythm, and the rhythm of responsiveness of… 

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References

SHOWING 1-10 OF 101 REFERENCES
Melatonin and the Circadian Regulation of Sleep Initiation, Consolidation, Structure, and the Sleep EEG
TLDR
It is demonstrated that melatonin exerts effects on the main characteristics of human sleep, that is, latency to sleep onset, sleep consolidation, slow waves, sleep spindles, an M sleep.
Contribution of the circadian pacemaker and the sleep homeostat to sleep propensity, sleep structure, electroencephalographic slow waves, and sleep spindle activity in humans
  • D.G.M. Dijk, C. Czeisler
  • Biology, Psychology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1995
TLDR
Analyses of the (nonadditive) interaction of the circadian and sleep-dependent components of sleep propensity and sleep structure revealed that the phase relation between the sleep-wake cycle and the circadian pacemaker during entrainment promotes the consolidation of sleep and wakefulness and facilitates the transitions between these vigilance states.
CONTRIBUTION OF CIRCADIAN PHYSIOLOGY AND SLEEP HOMEOSTASIS TO AGE-RELATED CHANGES IN HUMAN SLEEP
TLDR
The internal circadian phase advance of awakening, as well as the age-related reduction in sleep consolidation, appears related to an age- related reduction in the promotion of sleep by the circadian pacemaker during the biological night in combination with a reduced homeostatic pressure for sleep.
Evidence for a biological dawn and dusk in the human circadian timing system
TLDR
A model of the human circadian timing system in which two states, one diurnal and one nocturnal, alternate with one another is suggested, and in which transitions between the states are switch‐like and are separately entrained to dawn and dusk is suggested.
The Circadian Clock Mutation Alters Sleep Homeostasis in the Mouse
TLDR
Results indicate that genetic alterations of the circadian clock system and/or its regulatory genes are likely to have widespread effects on a variety of sleep and wake parameters, including the homeostatic regulation of sleep.
Ageing and the circadian and homeostatic regulation of human sleep during forced desynchrony of rest, melatonin and temperature rhythms
TLDR
Age‐related decrements in sleep consolidation and increased susceptibility to circadian phase misalignment in older people appear to be related to the interaction between a reduction in the homeostatic drive for sleep and a reduced strength of the circadian signal promoting sleep in the early morning.
Circadian temperature and melatonin rhythms, sleep, and neurobehavioral function in humans living on a 20-h day.
TLDR
The interaction of homeostatic and circadian processes in the regulation of waking neurobehavioral functions and sleep was studied in six healthy young subjects, demonstrating the exquisite of many neuro behavioral functions to circadian phase and the accumulation of homeOSTatic drive for sleep.
Timing of human sleep: recovery process gated by a circadian pacemaker.
TLDR
The model shows that the experimental data are consistent with the concept of a single circadian pacemaker in humans, which has implications for the understanding of sleep as a restorative process and its timing with respect to day and night.
Sleep Homeostasis and Models of Sleep Regulation
TLDR
Simulation of the time course of EEG slow-wave activity, the major marker of non-REM sleep homeostasis, as well as daytime alertness and nonlinear interactions between homeostatic and circadian processes were identified.
Peak of circadian melatonin rhythm occurs later within the sleep of older subjects.
TLDR
The findings indicate that aging is associated not only with an advance of sleep timing and the timing of circadian rhythms but also with a change in the internal phase relationship between the sleep-wake cycle and the output of the circadian pacemaker.
...
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