Integration of growth factor gene delivery with collagen‐triggered wound repair cascades using collagen‐mimetic peptides

  title={Integration of growth factor gene delivery with collagen‐triggered wound repair cascades using collagen‐mimetic peptides},
  author={Morgan A. Urello and Kristi L. Kiick and Millicent O. Sullivan},
  journal={Bioengineering \& Translational Medicine},
  pages={207 - 219}
Abstract Growth factors (GFs) play vital roles in wound repair. Many GF therapies have reached clinical trials, but success has been hindered by safety concerns and a lack of efficacy. Previously, we presented an approach to produce protein factors in wound beds through localized gene delivery mediated by biomimetic peptides. Modification of polyethylenimine (PEI) DNA polyplexes with collagen‐mimetic peptides (CMPs) enabled tailoring of polyplex release/retention and improved gene transfer… 

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