Integration of genome-wide transcriptional and genetic profiles provides insights into disease development and clinical heterogeneity in alopecia areata.

Abstract

Alopecia areata (AA), a non-scarring inflammatory hair loss disorder, is a complex disease determined by genetic and environmental factors that remain largely unknown. Re-analysis of genome-wide microarray data in 9 patient blood and 10 skin samples revealed transcriptional "hot spots" at chromosomes 1q21-q32, 11q12-q14, and 16p13-p13.3 (blood) and 6p21.3… (More)
DOI: 10.1016/j.ygeno.2011.08.009

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