Integration of genome-wide of Stat3 binding and epigenetic modification mapping with transcriptome reveals novel Stat3 target genes in glioma cells.

@article{Kruczyk2014IntegrationOG,
  title={Integration of genome-wide of Stat3 binding and epigenetic modification mapping with transcriptome reveals novel Stat3 target genes in glioma cells.},
  author={Marcin Kruczyk and Piotr Przanowski and Michal Dabrowski and Karolina Swiatek-Machado and Jakub Mieczkowski and Ola Wallerman and Anna Ronowicz and Arkadiusz Piotrowski and Claes Wadelius and Bozena Kaminska and Jan Komorowski},
  journal={Biochimica et biophysica acta},
  year={2014},
  volume={1839 11},
  pages={1341-50}
}
BACKGROUND Signal transducer and activator of transcription 3 (STAT3) is constitutively activated in many human tumors, including gliomas, and regulates the expression of genes implicated in proliferation, survival, apoptosis, angiogenesis and immune regulation. Only a small fraction of those genes has been proven to be direct STAT3 targets. In gliomas… CONTINUE READING