Integration of genetics and miRNA–target gene network identified disease biology implicated in tissue specificity

@inproceedings{Sakaue2018IntegrationOG,
  title={Integration of genetics and miRNA–target gene network identified disease biology implicated in tissue specificity},
  author={Saori Sakaue and Jun Hirata and Yuichi Maeda and Eiryo Kawakami and Takuro Nii and Toshihiro Kishikawa and Kazuyoshi Ishigaki and Chikashi Terao and Ken Suzuki and Masato Akiyama and Naomasa Suita and Tatsuo Masuda and Kotaro Ogawa and Kenichi Yamamoto and Yukihiko Saeki and Masato Matsushita and Maiko Yoshimura and Hidetoshi Matsuoka and Katsunori Ikari and Atsuo Taniguchi and Hisashi Yamanaka and Hideya Kawaji and Timo Lassmann and Masayoshi Itoh and Hiroyuki Yoshitomi and Hiromu Ito and Koichiro Ohmura and Alistair R R Forrest and Yoshihide Hayashizaki and Piero Carninci and Atsushi Kumanogoh and Yoichiro Kamatani and Michiel J. L. de Hoon and Kazuhiko Yamamoto and Yukinori Okada},
  booktitle={Nucleic acids research},
  year={2018}
}
MicroRNAs (miRNAs) modulate the post-transcriptional regulation of target genes and are related to biology of complex human traits, but genetic landscape of miRNAs remains largely unknown. Given the strikingly tissue-specific miRNA expression profiles, we here expand a previous method to quantitatively evaluate enrichment of genome-wide association study (GWAS) signals on miRNA-target gene networks (MIGWAS) to further estimate tissue-specific enrichment. Our approach integrates tissue-specific… CONTINUE READING

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