Integration of gene expression data into genome-scale metabolic models.

  title={Integration of gene expression data into genome-scale metabolic models.},
  author={Mats {\AA}kesson and Jochen F{\"o}rster and Jens Nielsen},
  journal={Metabolic engineering},
  volume={6 4},
A framework for integration of transcriptome data into stoichiometric metabolic models to obtain improved flux predictions is presented. The key idea is to exploit the regulatory information in the expression data to give additional constraints on the metabolic fluxes in the model. Measurements of gene expression from chemostat and batch cultures of Saccharomyces cerevisiae were combined with a recently developed genome-scale model, and the computed metabolic flux distributions were compared to… CONTINUE READING

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