Integration of gene expression and GWAS results supports involvement of calcium signaling in Schizophrenia.

@article{Hertzberg2015IntegrationOG,
  title={Integration of gene expression and GWAS results supports involvement of calcium signaling in Schizophrenia.},
  author={Libi Hertzberg and Pavel L. Katsel and Panos Roussos and Vahram Haroutunian and Eytan Domany},
  journal={Schizophrenia research},
  year={2015},
  volume={164 1-3},
  pages={92-9}
}
The number of Genome Wide Association Studies (GWAS) of schizophrenia is rapidly growing. However, the small effect of individual genes limits the number of reliably implicated genes, which are too few and too diverse to perform reliable pathway analysis; hence the biological roles of the genes implicated in schizophrenia are unclear. To overcome these limitations we combine GWAS with genome-wide expression data from human post-mortem brain samples of schizophrenia patients and controls, taking… CONTINUE READING

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