Integration of donor mesenchymal stem cell-derived neuron-like cells into host neural network after rat spinal cord transection.

@article{Zeng2015IntegrationOD,
  title={Integration of donor mesenchymal stem cell-derived neuron-like cells into host neural network after rat spinal cord transection.},
  author={Xiang Feng Zeng and Xue-Cheng Qiu and Yuan-huan Ma and Jing-jing Duan and Yuan-Feng Chen and Huai-Yu Gu and Jun-mei Wang and Eng-Ang Ling and Jin-lang Wu and Wutian Wu and Yuan-Shan Zeng},
  journal={Biomaterials},
  year={2015},
  volume={53},
  pages={184-201}
}
Functional deficits following spinal cord injury (SCI) primarily attribute to loss of neural connectivity. We therefore tested if novel tissue engineering approaches could enable neural network repair that facilitates functional recovery after spinal cord transection (SCT). Rat bone marrow-derived mesenchymal stem cells (MSCs), genetically engineered to overexpress TrkC, receptor of neurotrophin-3 (NT-3), were pre-differentiated into cells carrying neuronal features via co-culture with NT-3… CONTINUE READING
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