Integration of distinct intracellular signaling pathways at distal regulatory elements directs T-bet expression in human CD4+ T cells.

@article{Placek2009IntegrationOD,
  title={Integration of distinct intracellular signaling pathways at distal regulatory elements directs T-bet expression in human CD4+ T cells.},
  author={Katarzyna Placek and S. G. Gasparian and Maryaline Coffre and Sylvie Maiella and Emmanuel Sechet and Elisabetta Bianchi and Lars Rogge},
  journal={Journal of immunology},
  year={2009},
  volume={183 12},
  pages={
          7743-51
        }
}
T-bet is a key regulator controlling Th1 cell development. This factor is not expressed in naive CD4(+) T cells, and the mechanisms controlling expression of T-bet are incompletely understood. In this study, we defined regulatory elements at the human T-bet locus and determined how signals originating at the TCR and at cytokine receptors are integrated to induce chromatin modifications and expression of this gene during human Th1 cell differentiation. We found that T cell activation induced two… CONTINUE READING
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