Integration of differentiation signals during indirect flight muscle formation by a novel enhancer of Drosophila vestigial gene.

@article{Bernard2009IntegrationOD,
  title={Integration of differentiation signals during indirect flight muscle formation by a novel enhancer of Drosophila vestigial gene.},
  author={Fr{\'e}d{\'e}ric A. Bernard and Petar Kasherov and Sabrina Grenetier and Annie Dutriaux and Alain Zider and J{\"o}el Silber and Alexis Lalouette},
  journal={Developmental biology},
  year={2009},
  volume={332 2},
  pages={
          258-72
        }
}
The gene vestigial (vg) plays a key role in indirect flight muscle (IFM) development. We show here that vg is controlled by the Notch anti-myogenic signaling pathway in myoblasts and is regulated by a novel 822 bp enhancer during IFM differentiation. Interestingly, this muscle enhancer is activated in developing fibers and in a small number of myoblasts before the fusion of myoblasts with the developing muscle fibers. Moreover, we show that this enhancer is activated by Drosophila Myocyte… CONTINUE READING
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