Integration of cellular bioenergetics with mitochondrial quality control and autophagy.

  title={Integration of cellular bioenergetics with mitochondrial quality control and autophagy.},
  author={Bradford G. Hill and Gloria A. Benavides and Jack R. Lancaster and Scott Ballinger and Lou Dell'Italia and Zhang Jianhua and Victor M. Darley-Usmar},
  journal={Biological chemistry},
  volume={393 12},
Bioenergetic dysfunction is emerging as a cornerstone for establishing a framework for understanding the pathophysiology of cardiovascular disease, diabetes,cancer and neurodegeneration. Recent advances in cellular bioenergetics have shown that many cells maintain a substantial bioenergetic reserve capacity, which is a prospective index of ‘ healthy ’ mitochondrial populations.The bioenergetics of the cell are likely regulated by energy requirements and substrate availability. Additionally,the… CONTINUE READING
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