Integration of autopatching with automated pipette and cell detection in vitro.

  title={Integration of autopatching with automated pipette and cell detection in vitro.},
  author={Qiuyu Wu 吴秋雨 and Ilya Kolb and Brendan Callahan and Zhaolun Su and W A Stoy and Suhasa B Kodandaramaiah and Rachael Lee Neve and Hongkui Zeng and Edward S. Boyden and Craig R. Forest and Alexander A. Chubykin},
  journal={Journal of neurophysiology},
  volume={116 4},
Patch clamp is the main technique for measuring electrical properties of individual cells. Since its discovery in 1976 by Neher and Sakmann, patch clamp has been instrumental in broadening our understanding of the fundamental properties of ion channels and synapses in neurons. The conventional patch-clamp method requires manual, precise positioning of a glass micropipette against the cell membrane of a visually identified target neuron. Subsequently, a tight "gigaseal" connection between the… CONTINUE READING
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