Integration of a Phosphatase Cascade with the Mitogen-activated Protein Kinase Pathway Provides for a Novel Signal Processing Function*

@inproceedings{Chaudhri2010IntegrationOA,
  title={Integration of a Phosphatase Cascade with the Mitogen-activated Protein Kinase Pathway Provides for a Novel Signal Processing Function*},
  author={Virendra K. Chaudhri and Dhiraj Kumar and Manjari Misra and Raina Dua and Kanury V. S. Rao},
  booktitle={The Journal of biological chemistry},
  year={2010}
}
We mathematically modeled the receptor-dependent mitogen-activated protein kinase (MAPK) signaling by incorporating the regulation through cellular phosphatases. Activation induced the alignment of a phosphatase cascade in parallel with the MAPK pathway. A novel regulatory motif was, thus, generated, providing for the combinatorial control of each MAPK intermediate. This ensured a non-linear mode of signal transmission with the output being shaped by the balance between the strength of input… CONTINUE READING
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