Integration of TGF-ß and Ras/MAPK Signaling Through p53 Phosphorylation

@article{Cordenonsi2007IntegrationOT,
  title={Integration of TGF-{\ss} and Ras/MAPK Signaling Through p53 Phosphorylation},
  author={M. Cordenonsi and Marco Montagner and M. Adorno and L. Zacchigna and Graziano Martello and A. Mamidi and S. Soligo and S. Dupont and S. Piccolo},
  journal={Science},
  year={2007},
  volume={315},
  pages={840 - 843}
}
During development and tissue homeostasis, cells must integrate different signals. We investigated how cell behavior is controlled by the combined activity of transforming growth factor–β (TGF-β) and receptor tyrosine kinase (RTK) signaling, whose integration mechanism is unknown. We find that RTK/Ras/MAPK (mitogen-activated protein kinase) activity induces p53 N-terminal phosphorylation, enabling the interaction of p53 with the TGF-β–activated Smads. This mechanism confines mesoderm… Expand
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