Integration of Rule-Based Models and Compartmental Models of Neurons

@inproceedings{Sterratt2014IntegrationOR,
  title={Integration of Rule-Based Models and Compartmental Models of Neurons},
  author={David C. Sterratt and Oksana Sorokina and J. Douglas Armstrong},
  booktitle={HSB},
  year={2014}
}
Synaptic plasticity depends on the interaction between electrical activity in neurons and the synaptic proteome, the collection of over 1000 proteins in the post-synaptic density (PSD) of synapses. To construct models of synaptic plasticity with realistic numbers of proteins, we aim to combine rule-based models of molecular interactions in the synaptic proteome with compartmental models of the electrical activity of neurons. Rule-based models allow interactions between the combinatorially large… CONTINUE READING
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