Integration of RNAi and small molecule screens to identify targets for drug development.

@article{Drosopoulos2013IntegrationOR,
  title={Integration of RNAi and small molecule screens to identify targets for drug development.},
  author={Konstantinos Drosopoulos and Spiros Linardopoulos},
  journal={Methods in molecular biology},
  year={2013},
  volume={986},
  pages={97-104}
}
Cellular models for siRNA and small molecule high throughput screening have been widely used in the last decade to identify targets for drug discovery. As an example, we present a two-fold readout approach based on cell viability and multipolar phenotype. To maximize the discovery of potential targets and at the same time reduce the number of false… CONTINUE READING