Integration of Pig-a, micronucleus, chromosome aberration and comet assay endpoints in a 28-day rodent toxicity study with urethane.

@article{Stankowski2015IntegrationOP,
  title={Integration of Pig-a, micronucleus, chromosome aberration and comet assay endpoints in a 28-day rodent toxicity study with urethane.},
  author={Leon F Stankowski and Marilyn J. Aardema and Timothy E Lawlor and Kamala Pant and Shambhu Roy and Yong Xu and Reem H. Elbekai},
  journal={Mutagenesis},
  year={2015},
  volume={30 3},
  pages={335-42}
}
As part of the international Pig-a validation trials, we examined the induction of Pig-a mutant reticulocytes and red blood cells (RET(CD59-) and RBC(CD59-), respectively) in peripheral blood of male Sprague Dawley(®) rats treated with urethane (25, 100 and 250mg/kg/day) or saline by oral gavage for 29 days. Additional endpoints integrated into this study… CONTINUE READING