Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control.

@article{Mammucari2005IntegrationON,
  title={Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control.},
  author={Cristina Mammucari and Alice Tommasi di Vignano and Andrey A. Sharov and Joel R Neilson and Matthew C. Havrda and Dennis R. Roop and Vladimir A Botchkarev and Gerald R Crabtree and Gian Paolo Dotto},
  journal={Developmental cell},
  year={2005},
  volume={8 5},
  pages={665-76}
}
The Notch and Calcineurin/NFAT pathways have both been implicated in control of keratinocyte differentiation. Induction of the p21(WAF1/Cip1) gene by Notch 1 activation in differentiating keratinocytes is associated with direct targeting of the RBP-Jkappa protein to the p21 promoter. We show here that Notch 1 activation functions also through a second Calcineurin-dependent mechanism acting on the p21 TATA box-proximal region. Increased Calcineurin/NFAT activity by Notch signaling involves… CONTINUE READING

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