Integration of Life-Stage Physiologically Based Pharmacokinetic Models with Adverse Outcome Pathways and Environmental Exposure Models to Screen for Environmental Hazards.

@article{ElMasri2016IntegrationOL,
  title={Integration of Life-Stage Physiologically Based Pharmacokinetic Models with Adverse Outcome Pathways and Environmental Exposure Models to Screen for Environmental Hazards.},
  author={Hisham A. El-Masri and Nicole C. Kleinstreuer and Ronald N Hines and Linda S. Thompson Adams and Tamara L. Tal and Kristin K Isaacs and Barbara A Wetmore and Y M Tan},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2016},
  volume={152 1},
  pages={
          230-43
        }
}
A computational framework was developed to assist in screening and prioritizing chemicals based on their dosimetry, toxicity, and potential exposures. The overall strategy started with contextualizing chemical activity observed in high-throughput toxicity screening (HTS) by mapping these assays to biological events described in Adverse Outcome Pathways (AOPs). Next, in vitro to in vivo (IVIVE) extrapolation was used to convert an in vitro dose to an external exposure level, which was compared… CONTINUE READING

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SHOWING 1-10 OF 47 REFERENCES

The fetal circulation and essential organs-a new twist to an old tale.

  • Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • 2006
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Basic anatomical and physiological data for use in radiological protection: reference values. Published for the International Commission for Radiological Protection (ICRP)

J. Valentin
  • 2003
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL