Integration of Genomic Data for Inferring Protein Complexes from Global Protein–Protein Interaction Networks

@article{Zheng2008IntegrationOG,
  title={Integration of Genomic Data for Inferring Protein Complexes from Global Protein–Protein Interaction Networks},
  author={Huiru Zheng and Haiying Wang and David H. Glass},
  journal={IEEE Transactions on Systems, Man, and Cybernetics, Part B (Cybernetics)},
  year={2008},
  volume={38},
  pages={5-16}
}
Protein-protein interactions (PPIs) play crucial roles in virtually every aspect of cellular function within an organism. One important objective of modern biology is the extraction of functional modules, such as protein complexes from global protein interaction networks. This paper describes how seven genomic features and four experimental interaction data sets were combined using a Bayesian-networks-based data integration approach to infer PPI networks in yeast. Greater coverage and higher… CONTINUE READING
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