Integration of ERG gene mapping and gene-expression profiling identifies distinct categories of human prostate cancer.

@article{Jhavar2009IntegrationOE,
  title={Integration of ERG gene mapping and gene-expression profiling identifies distinct categories of human prostate cancer.},
  author={Sameer G Jhavar and Daniel E Brewer and Sandra Edwards and Zsofia Kote-Jarai and Gerhardt Attard and Jeremy P. Clark and Penny Flohr and Timothy Christmas and Alan Thompson and Matthew E Parker and Christopher Shepherd and U E Stenman and Tania Marchbank and Raymond J Playford and Christopher Woodhouse and Christopher Ogden and Cyril Fisher and Gyula Kov{\'a}cs and Cathy Corbishley and Charles Jameson and Andy Norman and Johann S De-Bono and Anders Bjartell and Rosalind A Eeles and Colin S Cooper},
  journal={BJU international},
  year={2009},
  volume={103 9},
  pages={1256-69}
}
OBJECTIVE To integrate the mapping of ERG alterations with the collection of expression microarray (EMA) data, as previous EMA analyses have failed to consider the genetic heterogeneity and complex patterns of ERG alteration frequently found in cancerous prostates. MATERIALS AND METHODS We determined genome-wide expression levels with GeneChip Human Exon 1.0 ST arrays (Affymetrix, Santa Clara, CA, USA) using RNA prepared from 35 specimens of prostate cancer from 28 prostates. RESULTS The… CONTINUE READING