Integration of DNA copy number alterations and prognostic gene expression signatures in breast cancer patients.

@article{Horlings2010IntegrationOD,
  title={Integration of DNA copy number alterations and prognostic gene expression signatures in breast cancer patients.},
  author={Hugo M. Horlings and Carmen Lai and Dimitry S. A. Nuyten and Hans Halfwerk and Petra Kristel and Erik H van Beers and Simon Andreas Joosse and Christiaan Klijn and Petra M. Nederlof and Marcel J. T. Reinders and Lodewyk F. A. Wessels and Marc van de Vijver},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2010},
  volume={16 2},
  pages={651-63}
}
PURPOSE Several prognostic gene expression profiles have been identified in breast cancer. In spite of this progress in prognostic classification, the underlying mechanisms that drive these gene expression patterns remain unknown. Specific genomic alterations, such as copy number alterations, are an important factor in tumor development and progression and are also associated with changes in gene expression. EXPERIMENTAL DESIGN We carried out array comparative genomic hybridization in 68… CONTINUE READING
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A comprehensive analysis of prognostic signatures reveals the high predictive capacity of the proliferation, immune response and RNA splicing modules in breast cancer

  • F Reyal, MH van Vliet, NJ Armstrong
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